25 June 2017, Volume 13 Issue 2

    

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  Super-early vascular recanalization in ischemic stroke

  YANG Ligang, GUAN Yangtai

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 61-65. https://doi.org/10.12022/jnnr.2017-0020

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  With the increasing incidence of ischemic stroke and the younger age of onset, active and effective recanalization of blood vessels and recovery of blood supply are important in super-early treatment of stroke and the functional rehabilitation in the late stage. At present, the main methods of vascular recanalization are intravenous thrombolysis, arterial thrombolysis, mechanical recanalization and bridging therapy. This paper introduces the current internationally accepted super-early recanalization methods in ischemic stroke, and discusses some controversial points in the clinical practice.
New Horizon
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  Dancing therapy in rehabilitation of Parkinson’s disease

  CHEN Hua, JIN Lirong, LI Yang, SHEN Yan, ZHOU Yu, JI Jianlin

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 66-69. https://doi.org/10.12022/jnnr.2017-0034

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  Parkinson’s disease (PD) is a neurodegenerative disorder, which affects central nervous system (CNS). Dancing therapy has been suggested to give benefits to emotional, physical, spiritual and cognitive functions and the interpersonal integration. Dancing therapy can also improve the coordination of limbs of patients with PD, improve their gait and movement fluency, and improve the balance, cognitive ability and self-efficacy. In 2001, the Dance for Parkinson’s Disease? training classes were developed by Mark Morris Dance Group and New York Brooklyn Parkinson Group. They incorporated the music and dance into the rehabilitation treatment of PD. This paper expounds the role of dancing therapy in rehabilitation treatment of PD, and introduces its development status domestic and abroad.
Original Research
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  Guiding education in rehabilitation nursing of children with cerebral palsy

  CHEN Yufen, LI Qiang, LUO Juanzi

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 70-73. https://doi.org/10.12022/jnnr.2016-0014

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  Objective: To explore the feasibility and efficacy of guiding education in rehabilitation nursing for children with cerebral palsy. Methods: From July 2015 to December 2016, 120 cases of cerebral palsy receiving rehabilitation nursing in Shenzhen Children’s Hospital were recruited in this study. They were randomly divided into study group (60 cases) and control group (60 cases). The control group received routine rehabilitation nursing, and the study group adopted rehabilitation nursing based on guiding education concept. The Gross Motor Function Measure (GMFM) was used to evaluate the rehabilitation efficacy of the 2 groups at the first visit and 24 weeks after the end of the treatment. Results: GMFM functional area scores of two groups were significantly increased 24 weeks after the end of the treatment as compared with those at the first visit (both P < 0.05). The study group had a higher score (84.37 ± 5.94) than the control group (68.77 ± 6.02) (P < 0.05). The total effective rate of the study group (86.7%, 52/60) was also significantly higher than that of the control group (68.3%, 41/60) (P < 0.05). Conclusion: The introduction of guiding education concept into rehabilitation nursing of children with cerebral palsy can significantly improve the effect of rehabilitation treatment, and is worthy of clinical application.
Review
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  Progress in application of induced pluripotent stem cells

  SUN Chuanhe, GAO Penglin, LIAO Weilong, JIANG Wenfei, PAN Weidong

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 74-79. https://doi.org/10.12022/jnnr.2017-0014

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  Induced pluripotent stem (iPS) cells can be directly generated from differentiated somatic cells by transduction, which is a great revolution in life sciences. iPS cells are similar to embryonic stem cells and have the potential to differentiate into mature cells, but the former can avoid immunological rejection and medical ethics which exists in the study of embryonic stem cells. Therefore, iPS cells have shown a good prospect in the field of basic and clinical research. This paper reviews the 10-year development course of iPS cells research, the use of iPS cells in many kinds of diseases and clinical drug monitoring, and the problems in the study, especially focusing on the application of iPS cells in nervous system diseases.
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  Application of neuro-electrophysiological techniques in sepsis-associated encephalopathy

  YU Min, ZHAN Qing

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 80-84. https://doi.org/10.12022/jnnr.2017-0024

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  Sepsis-associated encephalopathy (SAE) is a diffuse dysfunction of brain caused by systemic inflammation. It is often missed in clinical practice. At present, there is still a lack of unified and definite diagnostic criteria for SAE. The diagnosis is mainly based on clinical manifestations and electrophysiological and neuroimaging findings. As compared with computed tomography (CT) and magnetic resonance imaging (MRI), the changes of the disease in patients with SAE can be observed earlier by neuro-physiological techniques which are noninvasive and quick and the bedside operation can be conducted repeatedly. This paper reviews the progress in electroencephalogram and continuous electroencephalogram monitoring, somatosensory evoked potential, transcranial Doppler sonography and other neuro-physiological techniques in SAE.
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  Progress in etiology, prevention and treatment of vascular cognitive impairment without dementia

  LIAO Weilong, JIANG Wenfei, SUN Chuanhe, GAO Penglin, PAN Weidong

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 85-90. https://doi.org/10.12022/jnnr.2017-0015

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  With the aging of the population, vascular cognitive impairment without dementia has become a disease that affects the quality of life and gives the burdens to social economy and emotion. Vascular cognitive impairment without dementia is an early stage of vascular cognitive impairment. Early intervention can delay or even reverse the decline of cognitive function, improve the quality of life, and save medical resources. From the perspective of modern medicine and traditional Chinese medicine, this paper addresses the etiology and pathogenesis of vascular cognitive impairment without dementia, and at the same time reviews the advances in prevention and treatment of this disease, in order to provide theoretical basis for the clinical practice and scientific research.
Case Report
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  Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome: A case report and literature review

  HE Munan, QIN Baofeng, GONG Fan, LI Shaokang, YU Xiaofei, GUO Yongmei

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 91-97. https://doi.org/10.12022/jnnr.2017-0012

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  Objective: To improve the understanding of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode (MELAS) symdrom in clinical practice. Methods: The clinical manifestations, diagnosis and treatment of one case with MELAS syndrome were reported. The pathogenesis, clinical manifestations, diagnosis and treatment of MELAS syndrome were discussed based on literature review. Results: MELAS syndrome is a type of mitochondrial disease that mainly involves brain and muscle tissues and is associated with stroke-like episodes. It should be clinically differentiated from encephalitis and cerebral infarction. Early diagnosis and treatment can help prevent further development of the disease. Conclusion: The clinical manifestations of MELAS syndrome are complex and diverse. The long-term prognosis is poor and the mortality rate is high. Therefore, early diagnosis and treatment are of important clinical significance for improving the prognosis and quality of life of the patients with MELAS syndrome.
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  Autoimmune encephalitis accompanied with status epilepticus, dyskinesia and hypoventilation syndrome: A case report and literature review

  WANG Qinying, GU Qin, YU Min, JIANG Dudu, ZHAN Qing

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 98-103. https://doi.org/10.12022/jnnr.2017-0021

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  Objective: To summarize the clinical features of autoimmune encephalitis so as to reduce the clinical misdiagnosis. Methods: The diagnosis and treatment and the follow-up data of a young female patient with autoimmune encephalitis were reviewed retrospectively. Results: The patient had a fever as the initial symtom and the disease progressed rapidly with status epilepsy, motor disorders and hypoventilation syndrome. Immunotherapy was administered when the diagnosis of autoimmune encephalitis was confirmed. At the third month since the onset of the disease, the condition of the patient was gradually improved; at the fifteenth month, the patient achieved good prognosis. Conclusion: In clinical practice, a young patient with mental disorders, dyskinesia and epilepsy suspected of autoimmune encephalitis should receive detection of serum antibodies associated with autoimmune encephalitis and the cerebrospinal fluid test to make a definite diagnosis.
Teaching Research
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  Inferential teaching practice based on problem-based learning for complex cases in clinical teaching of integrative neurology

  PAN Weidong, JIANG Wenfei, SUN Chuanhe, LIAO Weilong, GAO Penglin

  Journal of Neurology and Neurorehabilitation. 2017, 13(2): 104-108. https://doi.org/10.12022/jnnr.2017-0029

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  Clinical teaching should not be a fixed and closed model. Its teaching guiding ideology should be open and constantly absorbs new teaching experiences with constant enrichment and development. Application of problem-based learning (PBL) with inferential teaching method for complex cases in clinical teaching of traditional Chinese medicine neurology can improve the clinical teaching level, enrich the teaching methods, and increase the teaching quality. In the teaching process, teachers guide the students to pay attention to the elusive and inferential properties of the medical history, clinical signs and the laboratory results of the patients which may be key factors in diagnosis through focusing on the concealment and reasoning of complex and difficult cases in neurology. By the PBL, the concept of integrated medicine for diagnosis and treatment of neurological diseases has been promoted, and the diagnosis and treatment according to the differentiation of the disease and syndrome in integrative neurology has been improved.