Progress in application of induced pluripotent stem cells

SUN Chuanhe; GAO Penglin; LIAO Weilong; JIANG Wenfei; PAN Weidong

doi:10.12022/jnnr.2017-0014

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Journal of Neurology and Neurorehabilitation ›› 2017, Vol. 13 ›› Issue (2) : 74-79. DOI: 10.12022/jnnr.2017-0014

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Progress in application of induced pluripotent stem cells

SUN Chuanhe, GAO Penglin, LIAO Weilong, JIANG Wenfei, PAN Weidong

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Abstract

Induced pluripotent stem (iPS) cells can be directly generated from differentiated somatic cells by transduction, which is a great revolution in life sciences. iPS cells are similar to embryonic stem cells and have the potential to differentiate into mature cells, but the former can avoid immunological rejection and medical ethics which exists in the study of embryonic stem cells. Therefore, iPS cells have shown a good prospect in the field of basic and clinical research. This paper reviews the 10-year development course of iPS cells research, the use of iPS cells in many kinds of diseases and clinical drug monitoring, and the problems in the study, especially focusing on the application of iPS cells in nervous system diseases.

Key words

Induced pluripotent stem cells / Nervous system diseases / Cardiovascular system diseases / Retinopathy / Communicable diseases / Drug monitoring

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SUN Chuanhe, GAO Penglin, LIAO Weilong, JIANG Wenfei, PAN Weidong. Progress in application of induced pluripotent stem cells[J]. Journal of Neurology and Neurorehabilitation. 2017, 13(2): 74-79 https://doi.org/10.12022/jnnr.2017-0014

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