Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome: A case report and literature review

HE Munan; QIN Baofeng; GONG Fan; LI Shaokang; YU Xiaofei; GUO Yongmei

doi:10.12022/jnnr.2017-0012

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Journal of Neurology and Neurorehabilitation ›› 2017, Vol. 13 ›› Issue (2) : 91-97. DOI: 10.12022/jnnr.2017-0012

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome: A case report and literature review

HE Munan1, QIN Baofeng1, GONG Fan1, LI Shaokang2, YU Xiaofei1, GUO Yongmei1

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Abstract

Objective: To improve the understanding of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode (MELAS) symdrom in clinical practice. Methods: The clinical manifestations, diagnosis and treatment of one case with MELAS syndrome were reported. The pathogenesis, clinical manifestations, diagnosis and treatment of MELAS syndrome were discussed based on literature review. Results: MELAS syndrome is a type of mitochondrial disease that mainly involves brain and muscle tissues and is associated with stroke-like episodes. It should be clinically differentiated from encephalitis and cerebral infarction. Early diagnosis and treatment can help prevent further development of the disease. Conclusion: The clinical manifestations of MELAS syndrome are complex and diverse. The long-term prognosis is poor and the mortality rate is high. Therefore, early diagnosis and treatment are of important clinical significance for improving the prognosis and quality of life of the patients with MELAS syndrome.

Key words

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode / Stroke-like episode / Differential diagnosis

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HE Munan, QIN Baofeng, GONG Fan, LI Shaokang, YU Xiaofei, GUO Yongmei. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome: A case report and literature review[J]. Journal of Neurology and Neurorehabilitation. 2017, 13(2): 91-97 https://doi.org/10.12022/jnnr.2017-0012

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Funding

Traditional Chinese Medicine Research Fund of Shanghai Municipal Commission of Health and Family Planning (No. 2012L021A); Shanghai Senior Integrated Medicine Talents Training Program of Three-year Action Plan of Traditional Chinese Medicine (No. ZY3-RCPY-4-2019); Traditional Chinese Medicine Encephalopathy Project of Shanghai Third Batch of Superior Specialized Subjects (No. ZYSNXD-YL-YSZK004)