Clinical teaching should not be a fixed and closed model. Its teaching guiding ideology should be open and constantly absorbs new teaching experiences with constant enrichment and development. Application of problem-based learning (PBL) with inferential teaching method for complex cases in clinical teaching of traditional Chinese medicine neurology can improve the clinical teaching level, enrich the teaching methods, and increase the teaching quality. In the teaching process, teachers guide the students to pay attention to the elusive and inferential properties of the medical history, clinical signs and the laboratory results of the patients which may be key factors in diagnosis through focusing on the concealment and reasoning of complex and difficult cases in neurology. By the PBL, the concept of integrated medicine for diagnosis and treatment of neurological diseases has been promoted, and the diagnosis and treatment according to the differentiation of the disease and syndrome in integrative neurology has been improved.