Abstract：Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent desuccinylase. It is mainly located in the mitochondrial matrix and is closely related to mitochondrial metabolism and redox process. In recent years, great progress has been made on the role of SIRT5 in cardiovascular and cerebrovascular diseases, neurodegenerative diseases and tumorigenesis. This review summarizes the latest progress in desuccinylation of SIRT5 and its mechanism in nervous system diseases.
肖志朋，张晓华. SIRT5去琥珀酰化及其在神经系统疾病中的作用机制[J]. 神经病学与神经康复学杂志, 2021, 17(1): 39-44.
XIAO Zhipeng, ZHANG Xiaohua. Desuccinylation of SIRT5 and its mechanism in neurological diseases. Journal of Neurology and Neurorehabilitation, 2021, 17(1): 39-44.
2021, Vol. 17 
