Performance evaluation of traditional Chinese medicine evaluation scale (ALS-SSIT scale) for therapeutic efficacy in amyotrophic lateral sclerosis
PAN Weidong1, WANG Qiudong2, ZHENG Xuanlu1, SIMA Dandan1, SCHRODER Joana1, WANG Mingzhe1
1. Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Department of Neurology of Integration of Traditional Chinese and Western Medicine, Shanghai Pudong New District Hospital of Traditional Chinese Medicine, Shanghai 200120, China
Abstract：Objective: To evaluate the feasibility, reliability, validity and sensitivity of ALS-SSIT scale—a traditional Chinese medicine (TCM) evaluation scale for therapeutic efficacy in amyotrophic lateral sclerosis (ALS).
Methods: To summarize the experience in traditional Chinese medicine (TCM) in the treatment of ALS and consult experts’ suggestions, and then develop a scale (ALT-SSIT scale) suitable for evaluating the efficacy of TCM in the treatment of ALS. The performance of ALSSSIT scale was evaluated on the day of enrollment and after 6-month of follow-up in 160 patients with ALS who received traditional Chinese medicine treatment. The SF-36 and ALSFRS-R scales were used as references to evaluate the feasibility, reliability, validity and sensitivity of ALS-SSIT scale.
Results: The acceptance and completion rates of ALS-SSIT scale were both higher than 99%. The test-retest reliabilities of ALS-SSIT scale were 0.917 and 0.918 on the day of enrollment and after 6-month of follow-up, respectively. The content validity and sensitivity (total score, score of each field and score of each item) were higher. There was a linear correlation between ALS-SSIT scale and SF-36 and ALSFRS-R scales, which means that ALS-SSIT scale could better reflect the changes in disease condition.
Conclusion: The feasibility, reliability, validity and sensitivity of ALS-SSIT scale in evaluating the efficacy of TCM in the treatment of ALS are satisfactory, which is suitable for clinical application.
潘卫东，王厹东，郑煊璐，司马旦旦，SCHRODER Joana,王明哲. 肌萎缩侧索硬化中医疗效评价量表（ALS-SSIT量表）的效能评价[J]. 神经病学与神经康复学杂志, 2021, 17(1): 13-18.
PAN Weidong, WANG Qiudong, ZHENG Xuanlu, SIMA Dandan, SCHRODER Joana, WANG Mingzhe. Performance evaluation of traditional Chinese medicine evaluation scale (ALS-SSIT scale) for therapeutic efficacy in amyotrophic lateral sclerosis. Journal of Neurology and Neurorehabilitation, 2021, 17(1): 13-18.
