“气虚血瘀”型缺血性脑卒中的中西医结合治疗机制与临床转化研究进展

李明哲

神经病学与神经康复学杂志 ›› 2025, Vol. 21 ›› Issue (3) : 238-247.

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PDF(2843 KB)
神经病学与神经康复学杂志 ›› 2025, Vol. 21 ›› Issue (3) : 238-247. DOI: 10.12022/jnnr.2025-0104
综述

“气虚血瘀”型缺血性脑卒中的中西医结合治疗机制与临床转化研究进展

  • 李明哲1,2,3
作者信息 +

Research progress on the mechanism of integrated traditional Chinese and western medicine therapy and clinical transformation for ischemic stroke with “qi deficiency and blood stasis”

  • LI Mingzhe1, 2, 3
Author information +
文章历史 +

摘要

脑卒中具有高发病率、高死亡率和高致残率的特点,由其引发的一系列功能障碍是 导致患者残疾的主要原因,因此脑卒中的康复治疗已成为脑血管疾病康复领域的研究热 点。脑卒中的发生与微循环障碍和能量代谢异常密切相关,同时中医理论认为其病机为 “本虚标实”。针对“气虚血瘀”型缺血性脑卒中(ischemic stroke,IS)患者,其康复治疗策 略主要集中在恢复神经功能、调控神经反射以及促进脑功能重塑。中医和西医治疗对 IS 患者均展现出良好的临床疗效。西医治疗以缺血再灌注为核心策略,但是血管再通后出 现的“无复流”现象以及神经保护剂的疗效争议限制了其临床疗效。中医治疗则通过益 气活血、调节肠道菌群-脑轴等整体干预手段,展现出其独特的优势。本文主要对中西医 协同干预治疗“气虚血瘀”型 IS 的临床方案进行阐述,系统梳理中医和西医治疗“气虚血 瘀”型 IS 的作用机制及其相关临床证据,并探索二者协同作用的增效路径。本文整合了 近 5 年的临床试验、基础研究和指南共识,以期为“气虚血瘀”型 IS 的中西医结合治疗提 供新的思路和方法,并为优化个体化治疗方案以及推动中西医结合疗法的国际化进程提 供科学依据。

Abstract

Stroke is characterized by high incidence, high mortality, and high disability rates. A series of functional impairments caused by stroke are the primary reasons for patient disability, making stroke rehabilitation a research hotspot in cerebrovascular disease recovery. The pathogenesis is characterized by underlying deficiency and manifesting excess, The occurrence of stroke is closely related to microcirculatory disorders and abnormal energy metabolism, while traditional Chinese medicine theory attributes its pathogenesis to “deficiency in origin and excess in manifestation”. For patients with ischemic stroke (IS) of the “qi deficiency and blood stasis”, rehabilitation strategies primarily focus on restoring neurological function, regulating neural reflexes, and promoting brain functional remodeling. Both traditional Chinese medicine and western medicine have shown favorable clinical efficacy in treating IS patients. Western medicine focusing on reperfusion after ischemia. However, its clinical outcomes are limited by the “no reflow” phenomenon after revascularization and controversies surrounding the efficacy of neuroprotective agents. Traditional Chinese medicine demonstrates unique advantages through tonifying qi and activating blood circulation, regulating gut microbiota-brain axis, and other holistic interventions. This article primarily discusses the clinical approaches for the synergistic intervention of traditional Chinese medicine and western medicine in “qi deficiency and blood stasis” type IS, systematically reviews the mechanisms and clinical evidences of both treatments, and explores synergistic enhancement pathways of them. By integrating clinical trials, basic research, and guideline consensus from the past five years, this review aims to provide new ideas and methods for the integrated traditional Chinese and western medicine therapy of “qi deficiency and blood stasis” type IS. It also seeks to offer a scientific basis for optimizing individualized treatment plans and advancing the internationalization of the integration traditional Chinese and western medicine.

关键词

缺血性脑卒中 / 气虚血瘀 / 中西医结合 / 治疗机制 / 研究进展

Key words

Ischemic stroke / Qi deficiency and blood stasis / Integrated traditional Chinese and western medicine / Therapy mechanism / Research progress

引用本文

导出引用
李明哲. “气虚血瘀”型缺血性脑卒中的中西医结合治疗机制与临床转化研究进展[J]. 神经病学与神经康复学杂志. 2025, 21(3): 238-247 https://doi.org/10.12022/jnnr.2025-0104
LI Mingzhe. Research progress on the mechanism of integrated traditional Chinese and western medicine therapy and clinical transformation for ischemic stroke with “qi deficiency and blood stasis”[J]. Journal of Neurology and Neurorehabilitation. 2025, 21(3): 238-247 https://doi.org/10.12022/jnnr.2025-0104

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