当前临床和研究领域的技术进步使得人们对阿尔茨海默病（Alzheimer’s disease，AD）有了更加深入和全面的了解。β-淀粉样蛋白（β-amyloid，Aβ）是 AD 的核心生物标志物，Aβ-PET 可以客观地检测脑内的异常 Aβ 沉积和分布情况，被广泛应用于 AD 的早期精准诊断和疗效评估。本文对AD生物标志物的检测方法及其优缺点进行阐述，重点介绍Aβ-PET在AD诊疗中的应用及价值。

Current technological advances in clinical and research fields have enabled people to have a deeper and comprehensive understanding of Alzheimer's disease (AD). β -Amyloid (Aβ) is the core biomarker of AD. Aβ-PET can objectively detect the abnormal Aβ deposition and distribution in the brain, and can be widely used in the early accurate diagnosis and therapeutic evaluation of AD. This article elaborates on the detection methods and advantages and disadvantages of AD biomarkers, with a focus on the application and value of Aβ-PET in the diagnosis and treatment of AD.