肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是一种渐进进展、无有效治疗方法的神经退行性疾病,严重危害人类健康。中医药在治疗 ALS 有较好疗效,并且有基础研究验证了中医药治疗 ALS 的疗效机制，但目前仍无较明确揭示中医药治疗 ALS理论机制的文章。本文从传统中医基础出发,基于先后天理论,以脾肾为核心阐释中医药治疗 ALS 的中医机制,结合现代医学科学研究,讨论 ALS 内外兼治的可行性和有效性，为今后中医药治疗 ALS 提供较好的理论依据。

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with noeffective treatment and a serious threat to human health. Traditional Chinese Medicine(TCM)has a good curative effect on ALS, and some basic studies have verified thecurative mechanism of TcM on ALS. At present, there is still no clear theoreticalmechanism of TCM on ALS. This article started from the foundation of TcM, based on thetheory of priori and the posterior, and explained the TcM of treating ALS with spleenand kidney as the core. Combined with modern medical scientific research, it discussed the feasibility and effectiveness of treating ALs both internally and externally, provided agood theoretical basis for the future treatment of ALS with TCM.