肉毒毒素( botulinum toxin,BT)是肉毒梭菌增殖过程中产生的一种细菌外毒素,属于神经毒素。肉毒毒素根据其抗原性的不同,分为 A、B、C、D、E、F和G7种亚型,其中A型 BTP被广泛应用于临床治疗,成为局灶性痉挛及肌张力障碍等疾病的首选治疗方法。国内批准上市的 A 型 BT 分别是 onabotulinumtoxinA(ONA)和 BTX-A。随着 ONA 和 BTX-A 在国内的临床应用日益广泛,2者在治疗上的作用效能差异越来越受到关注。本文比较了 ONA 和BTX-A 2种 A型 BT 临床疗效的差异,旨在为临床实践提供指导。

Botulinum toxin (BT)is a kind of bacterial exotoxin produced during the proliferation of Clostridium botulinum, which is classified as a neurotoxin. Based on its antigencity, BT is divided into 7 subtypes, including A, B, C, D, E, F and G. B'T type A has been widely used in clinical treatment, becoming the preferred treatment for focal spasm and dystonia. BT type A has been approved for marketing in China including onabotulinumtoxin A (ONA)and BTX-A. With the increasingly wide spread clinical application of ONA and BTX-A in China, the difference in therapeutic eficacy between ONA and BTX-A has attracted moreand more attention. Based on this, a comparison has been conducted to assess the difference in clinical effcacy to provide guidance for clinical practice.