高同型半胱胺酸血症是心脑血管疾病的独立危险因素。高同型半胱胺酸血症的发生与遗传因素、饮食、生活方式和个体因素有关。高同型半胱胺酸血症与高血压密切相关。近年来的大量研究表明，与单次血压值相比，24 h内血压值的变异性与靶器官的损伤更具相关性。高同型半胱胺酸血症与血压变异性之间的关系亦成为研究热点。最新研究发现，在原发性高血压和心脑血管疾病患者中，同型半胱胺酸水平升高是血压变异性增加的独立危险因素。高同型半胱胺酸血症导致血压变异性增加的可能机制包括：高同型半胱胺酸血症可激活肾素-血管紧张素系统，导致自主神经功能紊乱，以及加剧动脉粥样硬化等。

Hyperhomocysteinemia (HHcy) is an independent risk factor of vascular diseases. The occurrence of HHcy can be attributed to genetic factors, diet, life style and some individual factors. HHcy is closely associated with hypertension. Recently large amounts of studies have demonstrated that the end-organ damage is more closely related to 24-hour blood pressure variability than to single blood pressure values. Thus, the relationship between HHcy and blood pressure variability has been an important research issue. Recent studies have revealed that a higher serum homocysteine level is an independent risk factor for increased blood pressure variability. The mechanism of increased blood pressure variability caused by HHcy could be the activation of the renin-angiotensin system, induction of the dysfunction of the cardiovascular autonomic system, and exacerbation of atherosclerosis.