颈动脉支架置入术后脑高灌注综合征临床特征分析

姚东陂, 刘 鹏, 朱吉强, 张建林, 郑雪燕, 孙千贺, 缪中荣

神经病学与神经康复学杂志 ›› 2021, Vol. 17 ›› Issue (3) : 99-103.

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神经病学与神经康复学杂志 ›› 2021, Vol. 17 ›› Issue (3) : 99-103. DOI: 10.12022/jnnr.2021-0050
原创研究

颈动脉支架置入术后脑高灌注综合征临床特征分析

  • 姚东陂1,刘 鹏1,朱吉强1,张建林1,郑雪燕1,孙千贺1,缪中荣2
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Clinical features of cerebral hyperperfusion syndrome after carotid artery stent placement

  • YAO Dongpo1, LIU Peng1, ZHU Jiqiang1, ZHANG Jianlin1, ZHENG Xueyan1, SUN Qianhe1, MIAO Zhongrong2
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摘要

目的:探讨颈动脉支架置入术(carotid artery stenting,CAS)后并发脑高灌注综合征(cerebral hyperperfusion syndrome,CHS)患者的临床特征。

方法:回顾性分析 2017 年 6 月—2018 年 6 月 7 例 CAS 术后并发 CHS 患者的临床资料,分析术前计算机体层灌注(computed tomography perfusion,CTP)参数,评估灌注损伤分期,观察治疗结果和预后。

结果:7 例 CAS 术后并发 CHS 患者中,女性 1 例(14.3%),男性 6 例(85.7%);平均年龄为(64.0±6.7)岁 ;入院时诊断为短暂性脑缺血发作(transient ischemic attack,TIA)4 例(57.1%),脑梗死 3 例(42.9%);CHS 主要临床表现包括头痛 7 例(100.0%),高血压 4 例(57.1%),脑出血 2 例(28.6%);既往高血压史 6 例(85.7%),糖尿病史3 例(42.9%)。术前 CTP 灌注损伤分期 :2 期 2 例(28.6%)、3 期 5 例(71.4%),侧支循环代偿二级代偿 1 例(14.3%)、三级代偿 6 例(85.7%)。经脱水和降低颅内压治疗后,6 例(85.7%)恢复良好,1 例(14.3%)发生脑出血后进入昏迷状态。

结论:CAS 术后并发 CHS 会严重威胁患者的预后,要真正做到早识别和早干预以降低其危害。

Abstract

Objective: To investigate the clinical characteristics of patients with cerebral hyperperfusion syndrome (CHS) after carotid artery stenting (CAS).

Methods: The clinical data of 7 patients with CHS after CAS from June 2017 to June 2018 were retrospectively analyzed, the preoperative computed tomography perfusion (CTP) parameters were analyzed, the perfusion injury stages were evaluated, and the treatment outcomes and prognosis were observed.

Results: Among the 7 patients with CHS after CAS, there were one female (14.3%) and 6 males (85.7%). The average age was (64.0 ± 6.7) years. Transient ischemic attack (TIA) was diagnosed in 4 patients (57.1%) and cerebral infarction in 3 patients (42.9%). The main clinical manifestations of CHS included headache in 7 patients (100.0%), hypertension in 4 patients (57.1%) and intracerebral hemorrhage in 2 patients (28.6%). There were 6 patients (85.7%) with hypertension history and 3 patients with diabetes mellitus (42.9%). The preoperativestage of CTP perfusion injury was stage 2 in 2 patients (28.6%) and stage 3 in 5 patients (71.4%). Collateral circulation compensation was secondary compensation in one patient (14.3%) and tertiary compensation in 6 patients (85.7%). After dehydration and intracranial pressure reduction, 6 patients (85.7%) recovered, and one patient (14.3%) enteredcoma after intracerebral hemorrhage.

Conclusion: CHS after CAS seriously threatens to the prognosis of patients. Early recognition and early intervention must be achieved to reduce its harm.

关键词

高灌注综合征 / 颈动脉支架置入术 / 临床特征 / 脑脊液

Key words

Hyperperfusion syndrome / Carotid artery stenting / Clinical features / Cerebrospinal fluid

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导出引用
姚东陂, 刘 鹏, 朱吉强, 张建林, 郑雪燕, 孙千贺, 缪中荣. 颈动脉支架置入术后脑高灌注综合征临床特征分析[J]. 神经病学与神经康复学杂志. 2021, 17(3): 99-103 https://doi.org/10.12022/jnnr.2021-0050
YAO Dongpo1 , LIU Peng1 , ZHU Jiqiang1 , ZHANG Jianlin1 , ZHENG Xueyan1 , SUN Qianhe1 , MIAO Zhongrong2. Clinical features of cerebral hyperperfusion syndrome after carotid artery stent placement[J]. Journal of Neurology and Neurorehabilitation. 2021, 17(3): 99-103 https://doi.org/10.12022/jnnr.2021-0050

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