目的：扫视眼动能够快速完整地反映以基底节（basal ganglia，BG）为枢纽的神经网络执行过程，及时反映 BG 的工作状态和异常眼动情况。鉴于BG环路的复杂性，目前尚不清楚扫视行为影响帕金森病（Parkinson’s disease，PD）的机制。本研究通过监测早期PD患者的扫视眼动特征，探讨扫视眼动与 PD 疾病进展之间的关系。

方法：对30例原发性早期 PD 患者进行180d的随访，监测日常生活能力、PD 相关临床功能和神经心理认知功能以及扫视眼动功能，分析扫视潜伏期、扫视范围、峰值速度和反向扫视错误率，评估扫视特征与 PD 病程之间的关系。

结果：随访180d后，朝向扫视的扫视范围显著增加 [（10.35±1.00）° vs（9.94±0.35）°，P=0.037]， 反 向 扫 视 的 持 续 时 间 缩 短 [（62.93±22.91）ms vs（71.13±28.51）ms，P=0.027]。反向扫视的潜伏期越长，运动功能障碍越显著，并且不受认知功能的影响（r=0.609，P<0.001）。

结论：早期PD患者短期内即可出现扫视功能异常，如朝向扫视范围增加以及反向扫视 持续时间缩短。随着PD疾病的进展，较长的反向扫视潜伏期可能提示更严重的运动功能缺损。

Objective: Saccadic eye movement is highly involved in the neural network through basal ganglia (BG), which would contribute to the control and abnormalities of eye movement. However, given the complexity of BG circuit, the mechanism of how saccade is affected in Parkinson’s disease (PD) is uncertain. Therefore, this study was aim to analyze the characteristics and the correlation between saccades and disease progression by monitoring the saccadic eye movement in early PD patients.

Methods: Thirty patients with primary early PD were followed up for 180 days to monitor their activities of daily living, PD-related clinical function, neuropsychological cognitive function and saccadic eye movement function. Differences were compared between baseline and 180-day follow-up, including saccadic latency, duration, amplitude, peak velocity and antisaccadic error rate, in order to evaluate the relationship between saccade features and disease progression.

Results: During 180-day follow-up, patients performed better at prosaccade (PS) tasks than at baseline with a slight larger saccade (10.35±1.00 vs 9.94±0.35 degrees, P=0.037). They also had a shorter saccadic duration during antisaccade tasks (62.93±22.91 vs 71.13±28.51 ms, P=0.027). Antisaccadic latency was positively associated with motor disability, independent of cognitive performance (r=0.609, P<0.001).

Conclusion: Saccadic eye movement is probably affected in PD patients at early stage, with increased prosaccadic amplitude and decreased antisaccadic duration. With the development of disease, longer antisaccadic latency is positively associated with more serious motor disability.