Sirtuin 5（SIRT5） 属于烟酰胺腺嘌呤二核苷酸（nicotinamide adenine dinucleotide，NAD^＋）依赖性的去琥珀酰化酶，主要定位于线粒体基质，与线粒体内代
谢及氧化还原过程密切相关。近年来，有关SIRT5在心脑血管疾病、神经退行性疾病以及肿瘤发生中的作用研究取得重大进展。本文就Sirt5去琥珀酰化及其在神经系统疾病中作用机制的最新进展进行综述。

Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent desuccinylase. It is mainly located in the mitochondrial matrix and is closely related to mitochondrial metabolism and redox process. In recent years, great progress has been made on the role of SIRT5 in cardiovascular and cerebrovascular diseases, neurodegenerative diseases and tumorigenesis. This review summarizes the latest progress in desuccinylation of SIRT5 and its mechanism in nervous system diseases.