目的：提高农村地区及烧煤地区的群众及医护人员对一氧化碳（carbon monoxide，CO）中毒性脑病的认识。

方法：对1例老年男性重度CO中毒性脑病患者的诊疗经过进行详细描述，总结CO中毒性脑病的临床特征、诊断、治疗和预后。

结果：患者的重度CO中毒性脑病以瘫痪、认知能力下降和继发性癫痫为主要临床表现。经中西医结合治疗和康复训练治疗后，患者的瘫痪和认知能力逐渐改善，未有癫痫发作。

结论：CO中毒性脑病是急性CO中毒后的一种迟发性脑病，在救治急性CO中毒患者的同时，必须考虑神经系统后遗症的发生风险，尽早给予有效的干预措施以改善预后。

Objective: To improve the knowledge of carbon monoxide (CO) encephalopathy among the masses and medical staff in rural areas and coal-burning areas.

Methods: The clinical diagnosis and treatment of one elderly male patient with severe CO encephalopathy were described, and the clinical features, diagnosis, treatment and prognosis of this patient were summarized.

Results: The main clinical manifestations of this patient with severe CO encephalopathy were paralysis, cognitive decline and secondary epilepsy. After the treatment of integrated traditional Chinese and western medicine and rehabilitation training, the patient’s paralysis and cognitive ability gradually improved, and there was no epileptic seizure.

Conclusion: CO encephalopathy is a kind of delayed encephalopathy after acute CO poisoning. When treating patients with acute CO poisoning, the risk of neurological sequelae must be considered and effective intervention measures should be given as soon as possible to improve the prognosis.