目的：观察补气活血中药对糖尿病周围神经病变患者神经传导速度和血清超氧化物歧化酶（superoxide dismutase，SOD）及丙二醛（malondialdehyde，MDA）的影响。

方法：60 例糖尿病周围神经病变气虚血瘀证患者被随机分入补气活血中药组（30 例，糖尿病基础治疗联合补气活血中药治疗12 周）和对照组（30 例，糖尿病基础治疗12 周）。比较2 组患者治疗前后腓总神经传导速度以及血清SOD 和MDA 水平的变化，并且比较治疗后2 组的临床有效率。

结果：2 组患者治疗12 周后的腓总神经传导速度均较治疗前显著加快（P ＜ 0.05）；补气活血中药组治疗后的感觉神经传导速度较对照组显著加快（P ＜ 0.05），但运动神经传导速度的差异无统计学意义（P ＞ 0.05）。2 组治疗12 周后，血清SOD 水平均较治疗前显著升高（P ＜ 0.05），血清MDA 水平显著下降（P ＜ 0.05）；补气活血中药组治疗后的血清SOD 水平显著高于对照组（P ＜ 0.05），而血清MDA 水平显著低于对照组（P ＜ 0.05）。治疗12 周后，补气活血中药组临床有效率为93.3%，显著高于对照组的76.7%（P ＝ 0.001）。

结论：补气活血中药能够显著改善糖尿病周围神经病变患者的神经传导速度，其作用机制可能与抗氧化应激有关。

Objective: To observe the effects of Chinese medicine for reinforcing Qi and activating blood circulation on nerve conduction velocity and serum superoxide dismutase (SOD) and malondialdehyde (MDA) levels of patients with diabetic peripheral neuropathy.

Methods: Sixty diabetic peripheral neuropathy patients with Qi deficiency and blood stasis syndrome were randomly divided into two groups: Chinese medicine for reinforcing Qi and activating blood circulation group (30 cases, diabetes basic treatment combined with Chinese medicine for reinforcing Qi and activating blood circulation for 12 weeks) and control group (30 cases, diabetes basic treatment for 12 weeks). The changes of common peroneal nerve conduction velocity and serum SOD and MDA levels were compared between the two groups before and after treatment, and the clinical efficacy of the two groups was compared.

Results: The conduction velocities of the common peroneal nerve in the two groups after 12 weeks of treatment were significantly faster than those before treatment (P < 0.05); the conduction velocity of the sensory nerve in the Chinese medicine for reinforcing Qi and activating blood circulation group after treatment was significantly faster than that in the control group (P < 0.05), but there was no significant difference in the motor nerve conduction velocity (P > 0.05). After 12 weeks of treatment, serum SOD levels in both groups were significantly higher than those before treatment (P < 0.05), and the serum MDA levels were significantly lower (P < 0.05). After 12 weeks of treatment, the clinical effective rate of the Chinese medicine for reinforcing Qi and activating blood circulation group was 93.3%, significantly higher than 76.7% of the control group (P = 0.001).

Conclusion: Chinese medicine for reinforcing Qi and activating blood circulation can significantly improve the nerve conduction velocity in patients with diabetic peripheral neuropathy, and its mechanism may be related to antioxidant stress.