诱导多能干细胞应用研究进展

孙传河; 高鹏琳; 廖伟龙; 姜文斐; 潘卫东

doi:10.12022/jnnr.2017-0014

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神经病学与神经康复学杂志 ›› 2017, Vol. 13 ›› Issue (2) : 74-79. DOI: 10.12022/jnnr.2017-0014

综述

诱导多能干细胞应用研究进展

孙传河，高鹏琳，廖伟龙，姜文斐，潘卫东

作者信息 +

Progress in application of induced pluripotent stem cells

SUN Chuanhe, GAO Penglin, LIAO Weilong, JIANG Wenfei, PAN Weidong

Author information +

文章历史 +

摘要

利用体细胞重编程技术将已分化的体细胞转化为诱导多能干（induced pluripotent stem，iPS）细胞是生命科学领域的一个里程碑事件。iPS细胞与胚胎干细胞的作用类似，均有分化成机体各种成熟细胞的潜能，但前者可以避免胚胎干细胞研究中存在的免疫排斥和医学伦理等问题。因此，iPS细胞在基础及临床研究领域均展现出良好的应用前景。本文对iPS细胞历经10年的研究历程、iPS细胞目前在临床各类疾病及药物监测中的应用以及iPS细胞研究中存在的问题进行综述，重点阐述iPS细胞在神经系统疾病中的应用。

Abstract

Induced pluripotent stem (iPS) cells can be directly generated from differentiated somatic cells by transduction, which is a great revolution in life sciences. iPS cells are similar to embryonic stem cells and have the potential to differentiate into mature cells, but the former can avoid immunological rejection and medical ethics which exists in the study of embryonic stem cells. Therefore, iPS cells have shown a good prospect in the field of basic and clinical research. This paper reviews the 10-year development course of iPS cells research, the use of iPS cells in many kinds of diseases and clinical drug monitoring, and the problems in the study, especially focusing on the application of iPS cells in nervous system diseases.

导出引用

孙传河，高鹏琳，廖伟龙，姜文斐，潘卫东. 诱导多能干细胞应用研究进展[J]. 神经病学与神经康复学杂志. 2017, 13(2): 74-79 https://doi.org/10.12022/jnnr.2017-0014

SUN Chuanhe, GAO Penglin, LIAO Weilong, JIANG Wenfei, PAN Weidong. Progress in application of induced pluripotent stem cells[J]. Journal of Neurology and Neurorehabilitation. 2017, 13(2): 74-79 https://doi.org/10.12022/jnnr.2017-0014

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