目的 探讨吸烟及血浆同型半胱氨酸（homocysteine,Hcy）水平与男性高血压患者主要心脑血管事件（main cardiac-cerebral vascular event,MCCVE）发生率的关系。方法 选择355例男性高血压患者,按是否吸烟分为吸烟组（166例）和不吸烟组（189例）。收集患者的临床病历资料,并采用速率法测定血浆Hcy水平。评估吸烟及血浆Hcy水平与男性高血压患者MCCVE发生率的关系。应用logistic回归分析MCCVE相关危险因素。结果 吸烟组血浆Hcy水平[（17.74±12.64）μmol/L]高于不吸烟组[（15.37±5.37）μmol/L]（P<0.05）。吸烟组总的MCCVE发生率（57.83%）高于不吸烟组（44.44%）（χ2=9.324,P<0.05）。logistics回归分析结果显示,年龄、高血压病程、吸烟和血浆Hcy水平是MCCVE的独立危险因素（P值均<0.05）。其中,吸烟的比值比为1.786（95%可信区间：1.131~2.820）,血浆Hcy水平的比值比为1.035（95%可信区间：1.004~1.073）。结论 吸烟可使男性高血压患者血浆Hcy水平和MCCVE发生率均升高。年龄、高血压病程、吸烟和血浆Hcy水平是MCCVE的独立危险因素。
Abstract
Objective: To investigate the relationships between smoking and plasma homocysteine (Hcy) level with main cardiac-cerebral vascular events (MCCVEs) in male patients with hypertension.Methods: Three hundred and fifty-five male patients with hypertension were recruited in this study and divided into smoking group (n = 166) and non-smoking group (n = 189). The information of clinical records was collected. The plasma Hcy level was detected by velocity method. The relationships between smoking and plasma Hcy level with MCCVEs in male patients with hypertension were evaluated. The risk factors related to MCCVEs were examined using logistic regression analysis.Results: Plasma Hcy level in smoking group [(17.74±12.64) μmol/L] was higher than that in non-smoking group [(15.37±5.37) μmol/L] (P < 0.05). The incidence rate of MCCVEs in smoking group (57.83%) was higher than that in non-smoking group (44.44%) (χ2 = 9.324, P < 0.05). Logistic regression analysis showed that age, course of hypertension, smoking and plasma Hcy level were independent risk factors of MCCVEs (all P < 0.05). The odds ratio of smoking was 1.786 (95% confidence interval: 1.131-2.820) and the odds ratio of plasma Hcy level was 1.035 (95% confidence interval: 1.004-1.073).Conclusion: Smoking is associated with increased level of plasma Hcy and higher incidence rate of MCCVEs in patients with hypertension. The age, course of hypertension, smoking and plasma Hcy level are independent risk factors of MCCVEs.
关键词
高血压 /
吸烟 /
高半胱氨酸 /
心脑血管事件
Key words
Hypertension /
Smoking /
Homocysteine /
Cardiac-cerebral vascular events
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