1Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China2Department of Neurology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China；3Department of Neurorehabilitation, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China
Neural stem cell therapy, as a new therapeutic method for all kinds of nervous system diseases, has aroused wide concern for over 20 years since being first found in 1992. Ischemic stroke is highly concerned because of its high incidence, high mortality and high disability rate. The research advances in functions of endogenous neural stem cells in nerve regeneration and neovascularization and their interactions as well as the related regulators in these two important processes after ischemic stroke are summarized in this review, hoping to provide new ideas of accelerating neural functional recovery after ischemic stroke.
CHEN Miao, ZHAN Qing.
Endogenous neural stem cells and ischemic stroke[J]. Journal of Neurology and Neurorehabilitation. 2016, 12(3): 157-160 https://doi.org/10.12022/jnnr.2016-0044
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] REYNOLDS B A, WEISS S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992, 255(5052):1707-1710.
[2] GAGE F H. Mammalian, neural stem cell[J]. Science, 2000, 5457(287):2411-2438.
[3] LLOYD-JONES D, ADAMS R, CARNETHON M, et al. Heart disease and stroke statistics: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee[J]. Circulation, 2009, 119(3):21-181.
[4] DING D C, LIN C H, SHYU W C, et al. Neural stem cells and stroke[J]. Cell Transplant, 2013, 22(4):619-630.
[5] DARSALIA V, ALLISON S J, CUSULIN C, et al. Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain[J]. J Cereb Blood Flow Metab, 2011, 31(1):235-242.
[6] 李 通, 刘 畅. 神经干细胞移植与脑梗死[J]. 中国组织工程研究, 2013, 17(40):7175-7180.
[7] IBRAYEVA A，BONAGUIDI M A. Pushing and pulling on adult neural stem cells[J]. Cell Stem Cell, 2015, 16(5):451-452.
[8] 李 峰, 蔡光先. 脑缺血后神经再生及其治疗的研究进展[J]. 中华中医药杂志, 2016, 31(2):578-581.
[9] 张 波, 王任直, 刘建勇, 等. 鼠脑梗死后自体神经干细胞的原位增殖、分化及其可塑性[J]．中华神经外科杂志, 2004, 20(5):400-404．
[10] GHEUSI G, ORTEGA-PEREZ L, MURRAY K, et al. A niche for adult neurogenesis in social behavior[J]. Behav Brain Res, 2009, 200(2):315-322.
[11] SHEN C C, YANG Y C, CHIAO M T, et al. Characterization of endogenous neural progenitor cells after experimental ischemic stroke[J]. Cur Neurovasc Res, 2010, 7(1):6-14．
[12] FAIZ M, SACHEWSKY N, GASCóN S, et al. Adult neural stem cells from the subventricular zone give rise to reactive astrocytes in the cortex after stroke[J]. Cell Stem Cell, 2015, 17(5):624-634.
[13] 石海杉, 吴 文, 徐建兰. 内源性神经干细胞的研究进展[J]. 实用医学杂志, 2013, 29(19):3252-3254.
[14] KURZYK A. Agiogenesis-possibilities, problems and perspectives[J]. Postepy Biochem, 2015, 61(1):25-34.
[15] 姚瑞芹, 李 林. 血管内皮细胞生长因子在缺血性脑损伤中血管新生、神经发生和神经保护的作用[J]. 中国康复理论与实践, 2007, 13(3):208-211.
[16] MARTI H J, BERNAUDIN M, BELLAIL A, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia[J]. Am J Pathol, 2000, 156(3):965-976.
[17] SLEVIN M, KRUPINSKI J, SLOWIK A, et al. Serial measurement of vascular endothelial growth f act or and transforming growth factor beta 1 in serum of patients with acute ischemic stroke[J]. Stroke, 2000, 31(8):1863-1870.
[18] INOUE T, SUGIYAMA M, HATTORI H, et al. Stem cells from human exfoliated deciduous tooth-derived conditioned medium enhances recovery of focal cerebral ischemia in rats[J]. Tissue Eng Part, 2013, 19(1-2):24-29.
[19] ZAN L, WU H, JIANG J, et al. Temporal profile of Src, SSEcks, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema[J]. Neurochem Int, 2011, 58(8):872-879.
[20] YANG X T, BI Y Y, FENG D F. From the vascular microenvironment to neurogenesis[J]. Brain Res Bull, 2011, 84(1):1-7.
[21] 南 伟, 张海鸿, 伍亚民. 神经调控血管生成机制的研究进展[J]. 中国修复重建外科杂志, 2015, 29(12):1570-1573.
[22] IWAI M, SATO K, KAMADA H, et al. Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils[J]. J Cereb Blood Flow Metab, 2003, 23(3):331-341.
[23] HELDMANN U, THORED P, CLAASEN J H, et al. TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain[J]. Exp Neurol, 2005, 196(1):204-208.
[24] BEN-HUR T, BEN-MENACHEM O, FURER V, et al. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells[J]. Mol Cell Neurosci, 2003, 24(3):623-631.
[25] SHI B, DING J, LIU Y, et al. ERK1/2 pathway-mediated differentiation of IGF-1-transfected spinal cord-derived neural stem cells into oligodendrocytes[J]. PLoS One, 2014, 9(8):106038.
[26] THORED P, HELDMANN U, GOMES-LEAL W, et al. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke[J]. Glia, 2009, 57(8):835-849.
[27] HERMANN D M, PERUZZOTTI-JAMETTI L, SCHLECHTER J, et al. Neural precursor cells in the ischemic brain-integration, cellular crosstalk, and consequences for stroke recovery[J]. Front Cell Neurosci, 2014(8):291.
[28] CUNNINGHAM L A, CANDELARIO K, LI L. Roles for HIF-1α in neural stem cell function and the regenerative response to stroke[J]. Behav Brain Res, 2012, 227(2):410-417.
[29] 郑修元, 李胜活, 燕铁斌. 脑梗死与内源性神经干细胞[J]. 中国康复医学杂志, 2011, 26(8):783-787.
[30] 沈建英, 林 玲, 郑志竑. Notch信号通路在脑生发区神经干细胞维持与神经再生中的作用[J]. 中国细胞生物学学报, 2015, 37(4):588-593.
[31] 李 韩, 何家才. 干细胞治疗神经性疾病的最新研究进展[J]. 医学综述, 2015, 21(10):1729-1733.
[32] 彭楚雄, 彭争荣. 神经干细胞与高压氧[J]. 中国医学工程, 2015, 23(4):200-201.
