血管性痴呆的分子机制和遗传机制

刘晓惠, 刘学源

神经病学与神经康复学杂志 ›› 2016, Vol. 12 ›› Issue (2) : 87-93.

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神经病学与神经康复学杂志 ›› 2016, Vol. 12 ›› Issue (2) : 87-93. DOI: 10.12022/jnnr.2016-0041
综述

血管性痴呆的分子机制和遗传机制

  • 刘晓惠, 刘学源
作者信息 +

Molecular and genetic mechanism of vascular dementia

  • LIU Xiaohui, LIU Xueyuan
Author information +
文章历史 +

摘要

随着痴呆发病率的日渐升高,该病引起了越来越多的关注。痴呆已成为威胁人类,尤其是老龄人群健康的重要临床难题。血管性痴呆(vascular dementia,VaD)是仅次于阿尔茨海默病的痴呆常见类型之一,包括缺血性或出血性脑血管疾病或是心脏和循环障碍引起的低血流灌注所致的各种临床痴呆。VaD是有望预防和治疗的痴呆,因此是近年来的研究热点,本文对VaD的分子机制和遗传机制研究进展进行综述。

Abstract

With the increasing incidence of dementia, more and more attention has been given to this disease. It has already been a clinical difficult problem threatening the health of mankind, especially for the aged people. After Alzheimer's disease, vascular dementia (VaD) is the second leading cause of senile dementia, including ischemic or hemorrhagic cerebrovascular diseases or a variety of clinical dementia due to low blood flow induced by heart and circulatory disorders. VaD is a promising disease for prevention and treatment, and it has been a hot topic in recent years. Therefore, this article summarizes the recent advances in molecular and genetic mechanism of VaD.

关键词

痴呆 / 血管性 / 遗传学 / 基因 / 分子机制

Key words

Dementia, vascular / Genetic / Genes / Molecular mechanism

引用本文

导出引用
刘晓惠, 刘学源. 血管性痴呆的分子机制和遗传机制[J]. 神经病学与神经康复学杂志. 2016, 12(2): 87-93 https://doi.org/10.12022/jnnr.2016-0041
LIU Xiaohui, LIU Xueyuan. Molecular and genetic mechanism of vascular dementia[J]. Journal of Neurology and Neurorehabilitation. 2016, 12(2): 87-93 https://doi.org/10.12022/jnnr.2016-0041

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基金

国家自然科学基金面上项目(编号:81371212); 上海市科学技术委员会重点资助项目(编号:13411951102,13JC1404002)

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