帕金森病( Parkinson's disease,PD)是因中脑黑质纹状体多巴胺能神经元减少以及多巴胺-胆碱能系统失衡所致的一种常见的神经系统退行性疾病。PD 的临床症状除了典型的运动症状(motor symptoms,MS)如运动迟缓、静止性震颤、肌强直和姿势步态异常以外,还可以出现多种复杂的非运动症状(non-motor symptoms,NMS)，如自主神经功能障碍autonomic nervous dvsfunction,AD)、认知功能下降(coanitive decline,CD)和睡眠障碍等。其中,睡眠障碍作为 PD 常见的 NMS 之一,伴随着 PD 的整个病程,严重影响患者的生活质量,然而其发生机制目前尚不明确。本文对 PD 睡眠障碍的病理损伤机制、评估和治疗方法进行综述,以期为 PD 睡眠障碍的治疗提供新的思路。

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Parkinson's disease(PD)is a common neurodegenerative disorder caused by an imbalance of dopamine-cholinergic system in the nigra striatum leading to reduced level of dopaminergic neurons. Besides typical motor symptoms (MS)such as bradykinesia, static tremor, tonic muscle and abnormal postural gait, PD also manifests a series of complex non-motor symptoms (NMS),such as autonomic dysfunction, cognitive decline, sleep disorder, etc. Among them, sleep disorder as one of the most common PD NMS, can be seen in the whole course of PD disease, seriously affecting patients’ quality of life.However, the etiology of PD sleep disorder is still not clear. Therefore, this paper reviews the pathological mechanism, evaluation and treatment methods to provide new insights for PD sleep disorder management.