Multiple sclerosis (MS) is an inflammatory autoimmune demyelinating disease of the central nervous system. At present, the disease is mainly treated by glucocorticoid combined with immunosuppressive agent and interferon-β, and the therapy is pretty limited. In recent years, it has been found that mesenchymal stem cell (MSC), as a kind of pluripotent stem cell, can differentiate into nerve cells, thereby repairing damage. In this paper, the mechanism of MSC in the treatment of MS is discussed from multiple perspectives. MSC is expected to become a new method for the treatment of MS in the future.
Migraine is a common and disabling primary headache disorder, which brings significant economic burden to patients, families and society. The management of migraine is multifaceted, including acute treatment and preventive strategy. Non-steroidal antiinflammatory drugs are first-line treatment for mild to moderate migraine attacks, while triptans and preventive treatment are needed for moderate to severe migraine and chronic migraine attacks. Calcitonin gene-related peptide (CGRP) plays an important role in the pathogenesis of migraine, and promotes the development of CGRP antagonists and monoclonal antibodies against circulating CGRP which is released during migraine attacks or targeting its receptor. Recently, several monoclonal antibodies against CGRP or its receptors have been approved by the Food and Drug Administration of the United States for the treatment of episodic and chronic migraine. So far, the pathogenesis of migraine is not clear. The purpose of this paper is to review the progress in the pathogenesis and treatment of migraine, with particular attention to the potential role of anti-CGRP monoclonal antibodies in the prophylaxis of migraine.
Objective: To investigate the status of stigma and its influencing factors in patients with stroke.
Methods: A total of 408 patients with stroke who met the case selection criteria from November 2018 to February 2019 were enrolled in this study by convenient sampling. These 408 patients were evaluated by using self-designed demographic data questionnaire, stigma scale for chronic illness (SSCI), Hamilton depression scale (HAMD) (24 items) and social support rating scale (SSRS).
Results: The average score of stigma in 408 patients with stroke was 21.80+7.95, which was at a moderate level; the internal stigma score was 15.14+6.67 and the external stigma score was 6.65+3.38. Univariate analysis showed that occupation (P = 0.003), marital status (P = 0.001) and stroke type (P = 0.025) were significantly correlated with the level of stigma. The level of stigma was positively correlated with depression score (r = 0.247, P < 0.001), and negatively correlated with age (r = -0.140, P = 0.005), subjective support score (r = -0.241, P < 0.001) and support utilization score (r = -0.286, P = 0.012). Multiple linear regression analysis showed that age, depression score, subjective support score and support utilization score were significantly correlated with the stigma level of patients with stroke (P < 0.05).
Conclusion: The stigma of patients with stroke belongs to moderate level. The age, depression score, subjective support score and support utilization score are all influencing factors. By strengthening individual psychological intervention, establishing a good social support system and implementing effective rehabilitation training as soon as possible, it is of positive significance to reduce the level of stigma and improve the quality of life of patients with stroke.
Objective: To observe the effect of quality control circle activities on the incidence of orthostatic hypotension in hemiplegic patients with cerebrovascular diseases using electric standing bed.
Methods: The quality control circle activities group was established, and the activity themes were confirmed. The circulation management method was adopted to carry out the current situation investigation, the main causes analysis, the countermeasures decision and the effect evaluation. Ninety-four hemiplegic patients who met the case selection criteria from June to September 2018 were selected as the subjects before launching the quality control circle activities, and 94 hemiplegic patients who also met the case selection criteria from October to December 2018 were selected as the subjects after launching the quality control circle activities. A survey of the status quo was conducted, the main causes of orthostatic hypotension due to electric standing bed were analyzed, the corresponding countermeasures were decided, and the effect evaluation was carried out.
Results: The incidence of orthostatic hypotension decreased from 9.6% before launching the quality control circle activities to 2.1% after launching the quality control circle activities (P < 0.01), and the achievement rate and progress rate were 116.7% and 77.8%, respectively. Patient satisfaction increased from 69.1% to 97.9% (P < 0.01).
Conclusion: Quality control circle activity can reduce the incidence of orthostatic hypotension in hemiplegic patients using electric standing bed and improve their satisfaction.
The experience in diagnosis and treatment of a case of sarcoidosis with blurred vision, low fever, chest pain and deflection of angle of mouth as the main manifestations was reported. Through case discussion, it is clear that some systemic diseases which have not been documented in the literature of traditional Chinese medicine may be related to neuroimmune diseases. Based on the treatment principle of traditional Chinese medicine, most of the neuroimmune diseases are treated from liver, spleen and kidney, and the syndrome differentiation of these diseases is mostly deficiency of spleen and kidney yang. In addition, symptom-centered therapy should be emphasized, not only to improve the symptoms of patients based on syndrome differentiation and treatment principles, but also to relieve the adverse reactions of hormone shock therapy, which fully embodies the advantages of the combination of disease differentiation and syndrome differentiation in treatment of neurological diseases with integrative medicine.
