随着人口老龄化进程的加速与环境的变迁，神经系统变性疾病已经成为现代医学研究的热点领域，但此类疾病以病因不明、起病隐匿、疗效欠佳和预后不良为特征，严重影响患者的生存质量。本文阐释了神经系统变性疾病的病理学特点和临床特征，分享了本研究团队在中西结合辨治帕金森病和运动神经元病方面的临床实践经验与成果，并由此提出构建“三位一体”的中西结合辨治模式，将辨病与辨证相结合、宏观辨证与微观辨证相结合以及机能辨证与形态辨证相结合，以期充分发挥中医和西医的特长与协同优势，突破当前诊治的瓶颈，为神经系统变性疾病的防治提供新思路和新策略。

With the acceleration of population aging and environmental changes, neurodegenerative diseases have become a research hot spot in modern medical. However, these diseases are characterized by unknown etiology, insidious onset, suboptimal treatment efficacy, and poor prognosis, which seriously impact the life quality of patients. This article explains the pathological features and clinical characteristics of neurodegenerative diseases, and presents the clinical experience and achievements in the integrated traditional Chinese and western medicine approach for the differentiation and treatment of Parkinson's disease and motor neuron disease. Consequently, a "tripartite integrated" model of traditional Chinese and western syndrome differentiation and treatment is proposed, which combines disease differentiation with syndrome differentiation, macroscopic syndrome differentiation with microscopic syndrome differentiation, and functional syndrome differentiation with morphological syndrome differentiation. It aims to fully leverage the respective strengths and synergistic advantages of traditional Chinese medicine and western medicine, break through the bottleneck of current diagnosis and treatment, and provide new ideas and strategies for the prevention and treatment of neurodegenerative diseases.