Objective: To report one patient diagnosed of neuromyelitis optica spectrum disorder (NMOSD) receiving treatment with steroid combined with cyclophosphamide, and review the related literatures.
Methods: Laboratory examinations (including aquaporin-4 detection) and adjuvant examinations were performed on one patient with NMOSD, and the treatment with steroid combined with cyclophosphamide based on clinical practice was administrated.
Results: The patient suffered from progressive blurred vision of the right eye, accompanied by the weakness and numbness of the right limb, and was diagnosed of NMOSD. For treatment, this patient received steroid pulse therapy immediately after the NMOSD was confirmed, but the patient’s condition continued to progress and developed steroid-dependence. Then the cyclophosphamide was added and the patient’s condition was effectively controlled.
Conclusion: There is a significant benefit in NMOSD patients who are treated with steroid combined with cyclophosphamide when the only steroid treatment is ineffective.
Key words
Neuromyelitis optica spectrum disorder /
Aquaporin-4 /
Steroid /
Cyclophosphamide
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