Objective: To explore the feasibility and efficacy of guiding education in rehabilitation nursing for children with cerebral palsy. Methods: From July 2015 to December 2016, 120 cases of cerebral palsy receiving rehabilitation nursing in Shenzhen Children’s Hospital were recruited in this study. They were randomly divided into study group (60 cases) and control group (60 cases). The control group received routine rehabilitation nursing, and the study group adopted rehabilitation nursing based on guiding education concept. The Gross Motor Function Measure (GMFM) was used to evaluate the rehabilitation efficacy of the 2 groups at the first visit and 24 weeks after the end of the treatment. Results: GMFM functional area scores of two groups were significantly increased 24 weeks after the end of the treatment as compared with those at the first visit (both P < 0.05). The study group had a higher score (84.37 ± 5.94) than the control group (68.77 ± 6.02) (P < 0.05). The total effective rate of the study group (86.7%, 52/60) was also significantly higher than that of the control group (68.3%, 41/60) (P < 0.05). Conclusion: The introduction of guiding education concept into rehabilitation nursing of children with cerebral palsy can significantly improve the effect of rehabilitation treatment, and is worthy of clinical application.