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Physiological and pathological functions of astrocytes |
LIU Jie1, WANG Wenyuan1, 2 |
1. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201206, China
2. Huashan Hospital, Fudan University, Shanghai 200040, China |
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Abstract Astrocytes are important components of the central nervous system, which account for about 20%-30% of the total cells in the human brain. A large number of astrocytes have important physiological functions corresponding to their proportion, such as providing nutrients for neurons, regulating ionic and metabolic balance in the nervous system, and maintaining the structures of the brain and blood-brain-barrier. Furthermore, numerous studies have shown that astrocytes are actively involved in the development, maturation and pathological processes of the nervous system. This review gives a brief overview of the evolution and physiological functions of astrocytes, and the progress in the research of nervous system diseases.
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Received: 12 December 2019
Published: 20 January 2020
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Fund:National Key Research and Development Program of China (2016YFA05019026B1026, 2018YFA0107903)
National Natural Science Foundation of China (31471018) |
Corresponding Authors:
WANG Wenyuan E-MAIL ADDRESS: wywang@sioc.ac.cn
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