With in-depth research on motor function recovery after stroke, more and more literatures have reported that antidepressant and anxiety treatment is not only effective for post-stroke depression and anxiety, but also significantly promotes the recovery of motor function after stroke. In recent years, it has been studied whether the traditional Chinese and Western medicine drugs against depression and anxiety can improve the recovery of motor function in post-stroke patients, and its mechanism has been discussed. In this paper, the latest progress in the role and mechanism of Chinese and Western medicine in improving or independently improving the limb motor function in post-stroke patients is reviewed, in order to provide references for the prevention, treatment and rehabilitation of limb motor dysfunction after stroke.