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Advances in the use of monkey models for neurological disease cells and gene therapy |
PENG Jing1, ZHOU Qin2, CHEN Yongchang2 |
1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
2. Institute of Primate Translational Medicine, Kunming University of Science and Technology/Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650500, Yunnan Province, China |
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Abstract The physiological structure, brain structure and function, reproductive physiology and circadian rhythm of non-human primates are highly similar to those of humans. Therefore, primates model has significant and unique advantages in mechanism research and drug development of neurological diseases. In recent years, a variety of monkey models of neurological diseases has been gradually established using drug induction, physical injury and gene editing technology, providing an important experimental model for cell therapy, gene therapy and development of new drugs. In this review, the characteristics of monkey models and the advantages in cell and gene therapy of neurodegenerative diseases and inherited neurodevelopmental diseases are summarized, and the advances in the use of monkey models for neurological disease cells and gene therapy is reviewed, hoping to provide references for further investigation of disease mechanisms and advancement of preclinical and clinical research of new therapies using monkey models.
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Received: 12 December 2019
Published: 20 January 2020
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Fund:National Key Research and Development Program of China (2018YFA0107902)
National Natural Science Foundation of China (81930121) |
Corresponding Authors:
CHEN Yongchang E-MAIL ADDRESS: chenyc@lpbr.cn
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