Comments on Boston criteria version 2.0 for cerebral amyloid angiopathy

LI Shuang , DU Juan , SONG Yaying , WANG Gang

Journal of Neurology and Neurorehabilitation ›› 2025, Vol. 21 ›› Issue (3) : 147-157.

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Journal of Neurology and Neurorehabilitation ›› 2025, Vol. 21 ›› Issue (3) : 147-157. DOI: 10.12022/jnnr.2025-0041
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Comments on Boston criteria version 2.0 for cerebral amyloid angiopathy

  • LI Shuang1, DU Juan2, 3, SONG Yaying1, WANG Gang1
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Abstract

In 2022, the International Cerebral Amyloid Angiopathy Association published the Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRIneuropathology diagnostic accuracy study. This updated version has made significant revisions, including lowering the minimum age for diagnosing cerebral amyloid angiopathy, adding symptoms such as convexal subarachnoid hemorrhage, transient focal neurological episodes, and cognitive impairment/dementia, and incorporating multiple hemorrhagic and non-hemorrhagic imaging biomarkers. Compared with previous diagnostic versions, this latest version of the criteria demonstrates significantly improved diagnostic sensitivity, particularly in patients with symptomatic intracerebral hemorrhage. Therefore, this paper aims to summarize the Boston criteria version 2.0 for cerebral amyloid angiopathy with evidence from China Brain Bank and the clinical practice experience of our team as references for domestic peers.

Key words

Cerebral amyloid angiopathy / Boston criteria / Diagnostic criteria / Imaging marker

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LI Shuang , DU Juan , SONG Yaying , WANG Gang. Comments on Boston criteria version 2.0 for cerebral amyloid angiopathy[J]. Journal of Neurology and Neurorehabilitation. 2025, 21(3): 147-157 https://doi.org/10.12022/jnnr.2025-0041

Funding

Science and Technology Innovation 2030 Major Project:Neuroscience and Brain-like Research (2021ZD0201804)
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