
Amyloid-related imaging abnormalities: an MRI manifestation associated with Alzheimer's disease-targeted therapy with imaging characteristics and diagnostic specificity
CHU Shuguang, WANG Gang
Journal of Neurology and Neurorehabilitation ›› 2025, Vol. 21 ›› Issue (1) : 6-11.
Amyloid-related imaging abnormalities: an MRI manifestation associated with Alzheimer's disease-targeted therapy with imaging characteristics and diagnostic specificity
Amyloid-related imaging abnormalities (ARIA) are abnormal appearances on the image. In a narrow sense, the default refers specifically to abnormalities on MRI, not CT or PET. MRI findings are characteristic, including ARIA-E (edema/effusion) and ARIA-H (hemorrhage). These abnormalities occur only in patients with Alzheimer's disease (AD) and in specific disease scenarios, and are associated with β-amyloid (Aβ), which has diagnostic specificity. This article introduces the history and definition of ARIA, imaging manifestations and detection methods, severity grading of ARIA-E and ARIA-H, and clinical issues related to ARIA, in order to provide references for clinical identification and treatment of ARIA.
Alzheimer's disease / β-Amyloid / Amyloid-related imaging abnormalities (ARIA) / MRI
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