Amyloid-related imaging abnormalities: an MRI manifestation associated with Alzheimer's disease-targeted therapy with imaging characteristics and diagnostic specificity

CHU Shuguang, WANG Gang

Journal of Neurology and Neurorehabilitation ›› 2025, Vol. 21 ›› Issue (1) : 6-11.

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Journal of Neurology and Neurorehabilitation ›› 2025, Vol. 21 ›› Issue (1) : 6-11. DOI: 10.12022/jnnr.2024-0262
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Amyloid-related imaging abnormalities: an MRI manifestation associated with Alzheimer's disease-targeted therapy with imaging characteristics and diagnostic specificity

  • CHU Shuguang1,WANG Gang2
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Abstract

Amyloid-related imaging abnormalities (ARIA) are abnormal appearances on the image. In a narrow sense, the default refers specifically to abnormalities on MRI, not CT or PET. MRI findings are characteristic, including ARIA-E (edema/effusion) and ARIA-H (hemorrhage). These abnormalities occur only in patients with Alzheimer's disease (AD) and in specific disease scenarios, and are associated with β-amyloid (Aβ), which has diagnostic specificity. This article introduces the history and definition of ARIA, imaging manifestations and detection methods, severity grading of ARIA-E and ARIA-H, and clinical issues related to ARIA, in order to provide references for clinical identification and treatment of ARIA.

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Alzheimer's disease / β-Amyloid / Amyloid-related imaging abnormalities (ARIA) / MRI

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CHU Shuguang, WANG Gang. Amyloid-related imaging abnormalities: an MRI manifestation associated with Alzheimer's disease-targeted therapy with imaging characteristics and diagnostic specificity[J]. Journal of Neurology and Neurorehabilitation. 2025, 21(1): 6-11 https://doi.org/10.12022/jnnr.2024-0262

Funding

Important Weak Disciplines of Pudong New Area Health System Discipline Construction Project in 2022( PWZbr2022-14)
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