Objective:Enhance understanding of neuroautoimmune disorders associated with glutamic acid decarboxylase(GAD) antibodies to prevent misdiagnoses.

Methods:The clinical data of a patient primarily exhibiting stiff person syndrome was reported, reviewing symptomatology, pathogenesis,diagnostic processes, and treatment modalities based on existing literature.

Results:Symptoms in patients with GAD antibody-associated neurological syndrome vary and imaging results are often non-specific. The presence of GAD antibodies is crucial for accurate diagnosis. In this reported case, the patient showed improvement following plasma exchange therapy and maintained symptom stability with ongoing immunotherapy.

Conclusion:Stiff person syndrome frequently manifests in anti-GADantibody associated neurological syndromes. The intrathecal synthesis of GAD antibodies strongly supports diagnosis. Immunomodulatory therapy has proven effective in treating this condition.