Objective: To analyse a case report of "central- peripheral- central" rehabilitation modefor cognitive impairment in a patient with delayed encephalopathy after carbon monoxide poisoning (DEACMP), and to provide ideas for clinical cognitive impairment rehabilitation.

Methods:The clinical data, rehabilitation diagnosis, treatment process, and the changes ofcognitive function, language function and daily living ability of an adult patient withDEACMP were reported, and the efficacy was analyzed in conjunction with the relevantliterature.

Results: A 42 -year -old male patient was admitted to the hospital with“55 days ofcognitive impairment after carbon monoxide poisoning", and physical examinationrevealed that he was unable to speak, unresponsive, and uncooperative. MRl of the headshowed symmetrical patchy abnormal signals in the basal ganglia area and radiativecrown area, which was clinically diagnosed as DEACMP. The patient was given "hyperbaricoxygen therapy+transcranial magnetic stimulation+transcranial direct current+Schuelllanguage training+ognitive training"for central regulation, and "Lee Silverman VoiceTreatment (LSVT) training+daily living ability training" for peripheral intervention, withhis cognitive function had significantly improved. The score of modified Barthel index was15 points at admission and 60 points at discharge. The result showed that the patientcould achieve basic self- care in daily living.

Conclusion: DEACMP often leads to severe cognitive impairment, poor prognosis and highdisability rate. The application of"central-peripheral-central"rehabilitation mode tocognitive impairment of DEACMP can effectively promote the recovery of cognitivefunction in patients.