Objective: To investigate the related factors of infarct size of elderly patients with acute cardiogenic cerebral embolism (ACCE) .

Methods:The clinical data of ACCE patients over 65 years old who were admitted to the Department of Neurology, Shanghai Fourth People's Hospital from January 1, 2018 to November 30, 2021 were retrospectively collected. The patients according to infarct area showed by diffusion weighted imaging (DWI) sequence were divided into large, medium and small infarct size groups. The univariate statistical differences of clinical general data and blood test indexes of the three groups were compared respectively. Then applied multivariate logistic regression analysis to capered those significantly different related factors. 

Results: There were 146 elderly patients with ACCE, including 41 males and 105 females.Univariate analysis between large, medium, and small size groups suggested age, National nstitute of Health Stroke Scale (NIHSS)score, Glasgow Coma Scale (GCS)score, modified Rankin Scale (mRS) score, in-hospital mortality, blood sodium ions, blood chloride ions blood magnesium ions, high-sensitivity C-reactive protein(hsCRP), brain natriuretic peptide (BNP), D-dimer, and neutrophil to lymphocyte ratio (NLR)were statistically significant Multivariate logistic regression analysis indicated age lodds ratio (OR): 1.062 (95%confidence interval: 0.029-0.108);P<0.01,NIHSS score OR:18.139 (95% confdenceinterval: 1.001-4.680); P<0.01,hsCRP (OR:1.086 (95% confdence interval: 0.027-0.138)P<0.01], BNP (OR: 1.001 (95% confidence interval: 0.000-0.002); P<0.01], and NLR [OR.1.053 (95% confidence interval: 0.000-0.111); P<0.05]were independent risk factors forinfarct size of elderly patients with ACCE. 

Conclusion: Age, NIHSS, hsCRP, BNP and NLR are significantly correlated with infarct sizeof elderly patients with ACCE. Besides, hsCRP, BNP and NLR are monitoring indicators that should be paid more attention in the prevention and treatment of ACCE in the elderly especially with large area cerebral infarction.