Antibiotics are one of the most commonly used drugs in clinical practice. More and more evidence has shown the relationship between antibiotic drugs and epileptic seizures. Antibiotic drugs can cause seizures by acting on the central nervous system or affect the control of seizures by interaction with antiepileptic drugs. Seriously they may lead to status epilepticus and threaten the patients’ life. Seizures related to antibiotic drugs are mostly generalized tonic-clonic,but some are non-convulsive and make it difficult to be recognized. Consequently, it is critical for clinicians to know the influences of antibiotics on seizures. The impacts of different antibiotically drugs on epileptic seizures, their underlying mechanisms and predisposing factors are summarized in this paper. The purpose of this paper is to improve clinicians, especially non-neurologists’ understanding of the relationship between antibiotic drugs and seizures, helping clinicians identify high-risk patients, timely identify and deal with antibiotics-related seizures, and provide help for clinicians to make reasonable decisions.