The domestic epidemic of coronavirus disease 2019 (COVID-19) has been significantly improved, but the number of oversea cases and imported cases is on the rise. Relevant prevention and control measures still need to be paid attention to. Botulinum toxin injection is an important method for the treatment of spasticity, dystonia and other diseases. The operation process requires close contact with the patients and there is a risk of infection. In order to meet the needs of patients receiving botulinum toxin injection during the epidemic period, and to guide relevant medical personnel to make reasonable protection, this consensus is hereby formulated to ensure the safety of both doctors and patients.