Objective: To improve the clinical cognition of antibodies overlapping inflammatory demyelinating disease (IDD) in the central nervous system (CNS).

Methods: A 43-year-old male case of optic neuritis followed by multiple intracranial lesions successively is reported. The clinical manifestations and possible pathogenesis of demyelinating diseases mediated by anti-myelin oligodendrocyte glycoprotein (MOG-ab) and anti-myelin basic protein (MBP-ab) are discussed based on literature review.

Results: Despite extensive intracranial lesions and visual field defects, the patient recovered well after plasmapheresis, and there was no short-term recurrence in immunosuppressive therapy.

Conclusion: Therefore, when CNS-IDD are considered, it is important to detection of CNS demyelinating antibodies for early diagnosis, treatment and reduce functional disability.