Objective: To explore the effectiveness and safety of treatment with low molecular heparin combined with warfarin for patients diagnosed of cerebral venous sinus thrombosis (CVT) in puerperium.

Methods: The clinical diagnosis and treatment of a patient with CVT in puerperium were reported. The clinical characteristics of CVT and the related progress in diagnosis and treatment of CVT were reviewed.

Results: A patient suffered from headache, vomiting and seizure in puerperium. The lumbar puncture was conducted, showing significantly increased intracranial pressure. The superior magnetic resonance venography (MRV) showed superior sagittal sinus thrombosis. Based on clinical manifestations and examinations, this patient was diagnosed of CVT. Low molecular heparin combined with warfarin were given to the patient, and the condition was effectively controlled.

Conclusion: For patients with CVT, anticoagulant therapy is safe and effective, and thrombolytic therapy is feasible when it is necessary.