Objective: To report the diagnosis and treatment of a patient with acute ischemic stroke caused by traumatic internal carotid artery occlusion, and review the related literatures. Methods: The clinical diagnosis and treatment of a patient with acute ischemic stroke caused by traumatic internal carotid artery occlusion was reported. The clinical characteristics of traumatic internal carotid artery occlusion and the related progress in diagnosis and treatment of this disease were reviewed. Results: A patients with acute ischemic stroke caused by traumatic internal carotid artery occlusion received intravenous thrombolysis. After 2-week treatment, the right limb function was recovered, only leaving moderate motor aphasia, and the National Institute of Health Stroke Scale (NIHSS) score was 2. After 6-week treatment, the carotid artery computed tomography angiography (CTA) suggested the proximal stenosis of left common carotid artery and the distal common carotid artery occlusion extending to the bifurcation of the common carotid artery. Then the left carotid endarterectomy was performed with embolectomy and carotid angioplasty and stenting. After operation, the patient was followed-up, and the prognosis was good. Conclusion: For patients with acute ischemic stroke caused by traumatic internal carotid artery occlusion, individualized treatment is recommended on the basis of guidelines. The thrombolytic therapy in time window can improve the prognosis of the patients.