Objective: To investigate the efficacy of Lianshen Fengxin Decoction, a formula of Traditional Chinese Medicine, in treatment of excessive salivation and frequent urination overnight in patients with motor neuron disease (MND).
Methods: Fifty-two eligible patients with MND suffering with excessive salivation and frequent urination overnight who were outpatients or inpatients from Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between June, 2014 and November, 2016 were recruited in this study. The patients were randomly divided into two groups: Lianshen Fengxin Decoction group (n = 26, receiving routine Western medicine in combination with Lianshen Fengxin Decoction for 6 weeks) and routine Western medicine group (n = 26, only receiving routine Western medicine for 6 weeks). The overnight activity, quantity of salivation (24 h) and frequency of urination overnight as the primary measurements, and the score of Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) as the secondary mesurement were used to evaluate the clinical efficacy of Lianshen Fengxin Decoction.
Results: There were no significant differences in overnight activity, quantity of salivation (24 h), frequency of urination overnight and ALSFRS score before treatment between two groups (all P > 0.05). At the end of 6-week treatment, there were 4 patients and 5 patients dropped out or lost to follow-up in Lianshen Fengxin Decoction group and routine Western medicine group, respectively. The overnight activity, quantity of salivation (24 h) and the frequency of urination overnight were significantly decreased after treatment as compared with those before treatment in Lianshen Fengxin Decoction group (all P < 0.05), but there were no significant changes observed in routine Western medicine group (all P > 0.05). The ALSFRS score in two groups had no significant changes after treatment (both P > 0.05). No obvious liver and renal dysfunctions were observed in two groups.
Conclusion: Traditional Chinese Medicine formula—Lianshen Fengxin Decoction, which has the function of tonifying the kidney and the astringent effect, can obviously decrease the quantity of salivation and frequency of urination overnight in patients with MND.
Key words
Motor neuron disease /
Amyotrophic lateral sclerosis /
Sialorrhea /
Nocturia /
Lianshen Fengxin Decoction /
Actigraphy
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Funding
General Project of National Natural Science Foundation of China (No. 81373619)
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