This paper reports the diagnosis and management of a 65-year-old male patient with Morvan’s syndrome presenting with neurological symptoms including myokymia, myasthenia, hyperhidrosis, sleeping disorder and visual hallucination. Diagnostic examination revealed probable malignant lesion of the thymus gland, and the abnormality in immunologic function including positive expression of peripheral blood anti-voltage-gated potassium channel antibodies. This patient was definitely diagnosed of Morvan’s syndrome and reached clinical partial recovery after symptomatic and supportive treatment.
Key words
Morvan’s syndrome /
Dyskinesias /
Potassium channels, voltage-gated /
Anti-voltage-gated potassium channel antibodies
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] ASTRUC P. Augustin-Marie Morvan[J]. Prog Med, 1957, 85(7-8):177-178.
[2] BARBER P A,ANDERSON N E,VINCENT A. Morvan’s syndrome associated with voltage-gated K channel antibodies[J]. Neurology, 2000, 54(3):771-772.
[3] LIGUORI R, VINCENT A, CLOVER L, et al. Morvan’s syndrome: peripheral and central nervous system and cardiac involvement with antibodies to voltage-gated potassium channels[J]. Brain, 2001, 124(Pt 12):2417-2426.
[4] ISAACS H.A syndrome of continuous muscle fibre activity[J]. J Neurol Neurosurg Psychiatry, 1961, 24(4):319-325.
[5] ABGRALL G, DEMERET S, ROHAUT B, et al. Status dissociatus and disturbed dreaming in a patient with Morvan syndrome plus myasthenia gravis[J]. Sleep Med, 2015, 16(7):894-896.
[6] LAURENCIN C, ANDRé-OBADIA N, CAMDESSANCHé J P, et al. Peripheral small fiber dysfunction and neuropathic pain in patients with Morvan syndrome[J]. Neurology, 2015, 85(23):2076-2078.