Objective: To evaluate the predictors for ocular myasthenia gravis (OMG) conversing to secondary generalized myasthenia gravis (GMG). Methods: Thirty-three patients initially diagnosed of OMG were followed-up for three years to observe the progression of the disease. According to the outcomes at the end of the follow-up, the patients were divided into two groups: OMG group (n = 13, maintaining OMG) and GMG group (n = 20, conversing to GMG). The clinical characteristics and laboratory findings were compared between the two groups. Results: The quantitative myasthenia gravis score (QMGS), positive rates of anti-acetylcholine receptor antibody (AChRAb) and antinuclear antibody and the incidence rates of accompanying with thymoma and diabetes of GMG group were all significantly higher than those of the OMG group (all P < 0.05). Conclusion: This study suggests that higher QMGS, positive expressions of AChRAb and antinuclear antibody and accompanying with thymoma and diabetes may be used as the predictors for the poor outcomes of OMG conversing to GMG.
Key words
Myasthenia gravis, ocular /
Myasthenia gravis, generalized /
Prognosis /
Predictive factors
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