A case report and review of a patient with anti MDA 5antibody positive dermatomyositis

CHEN Changxia, HU Gongwei, BAl Chenyuan, WEN Huizi, WU Yi, YANG Hong

Journal of Neurology and Neurorehabilitation ›› 2023, Vol. 19 ›› Issue (2) : 37-43.

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Journal of Neurology and Neurorehabilitation ›› 2023, Vol. 19 ›› Issue (2) : 37-43. DOI: 10.12022/innr.2023-0090
Case Report

A case report and review of a patient with anti MDA 5antibody positive dermatomyositis

  • CHEN Changxia1, HU Gongwei1, BAI Chenyuan1,WEN Huizi1,WU Yi2,YANG Hong1
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Abstract

Objective: To evaluate the effect of combination of medical treatment and rehabilitation training on the recovery of patients with dermatomyositis.

Methods: A retrospective review of the clinical data, the course of diagnosis and treatment and the changes in the clinical status of 1 adult patient with anti MDA5 antibody positive dermatomyositis was conducted in coniunction with the relevant literature.

Results: Anti MDA5 antibody positive dermatomyositis as a subtype of dermatomyositis with variable clinical presentation and rapid progression. It should be aggressively treated with combined immunosuppressive therapy. The  patient in this case received multiple immunosuppressive therapies combined with rehabilitation training,and the therapeutic effect was good. Her weight was 37.5 kg at admission and 42.5 kg at discharge. Kubota water swallow test showed admission grade 4,recovery to grade 1 on discharge, and normal diet, Barthel index was 60 at admission and  returned to 80 at discharge, and independent of stairs.

Conclusion:Dermatomyositis is an occult chronic disease with multiple systemic involvement and poor muscle function in most patients. Establishment of an individualized early rehabilitation program facilitates functional recovery.

Key words

Dermatomyositis / Anti melanoma differentiation related gene 5 antibody / Dysphagia / Rehabilitation

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CHEN Changxia, HU Gongwei, BAl Chenyuan, WEN Huizi, WU Yi, YANG Hong. A case report and review of a patient with anti MDA 5antibody positive dermatomyositis[J]. Journal of Neurology and Neurorehabilitation. 2023, 19(2): 37-43 https://doi.org/10.12022/innr.2023-0090

Funding

National Natural Science Gene Youth Project (82201495)
Shanghai Municipal Health Commission General Project (202140414)
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