Objective: To observe the clinical efect of Fengxuanning prescription combined with betahistine in the treatment of peripheral vertigo.

Methods: A prospective study included 70 patients with peripheral vertigo who received treatment in the Department of Neurology, Shanghai TCM-Integrated Hospital from July 2021 to January 2023. They were randomly divided into betahistine group (35 cases,receiving betahistine alone)and Fengxuanning prescription combined with betahistine group (35 cases,receiving Fengxuanning prescription combined with betahistine) using a random number table method. The symptom scores, brainstem auditory evoked potential (BAEP) vestibular finction, hemorheology and treatment-related adverse reactions between the two groups were compared.

Results: Before treatment,there were no significant differences in symptoms such as dizziness, fatigue, weakness, tinnitus, deafness,nausea and vomiting,and abnormal sweating/nystagmus scores as well as the comprehensive symptom score between the two groups (all P>005). After treatment, the dizziness, fatigue, weakness, tinnitus deafness, nausea and vomiting,and abnormal sweating/nystagmus scores as well as the comprehensive symptom scores of the two groups were lower than those before treatment (all P<0.05). The dizziness,fatigue, weakness,tinnitus, deaness, nausea and vomiting and abnormal sweating/nystagmus scores as well as the comprehensive symptom score of the Fengxuanning prescription combined with betahistine group were lower than those of the betahistine group (all P<005). The abnormal rates of BAEP, caloric test electronystagmography and head thrust test (HIT results of the Fengxuanning prescription combined with betahistine group were lower than those of the betastatin group (all P<005), and the incidence of adversereactions was 8.57% (3/35, which was lower than 34.29% (12/35) of the betahistine group(P<0.05). The plasma viscosity, whole blood low and high shear viscosities, and red blood cell aggregation index of the Fengxuanning prescription combined with betahistine group were lower than those of the betastatin group(all P<0.05).

Conclusion: Compared with using betahistine alone, Fengxuanning prescription combined with betahistine has better effects in the treatment of peripheral vertigo.