Objective: To explore the regularity of the structural changes of the ganglion cell layer inthe retinal macular region of Parkinson's disease (PD), and to provide guidance for theearly diagnosis and condition assessment of PD.

Methods: 45 patients with primary PD (PD group) and 30 healthy volunteers who matchedthe age of PD group (control group) were enrolled from Quanzhou First Hospital, FujianAll subjects used optical coherence tomography (OcT) to measure the thickness and volume of ganglion cell layer, and statistically analyzed the differences between PD group andcontrol group. Pearson correlation analysis method was used to analyze the correlationbetween ganglion cell layer parameters and Movement Disorder Society Unifed-ParkinsonDisease Rating Scale I (MDS-UPDRS Il)score and Hoehn-Yahr (H-Y) grade in PDpatients.

Results: Compared with the control group, the ganglion cell layer in the macular area ofPD group were thinner (P<0.05)and smaller (P<0.05). The thickness and volume ofganglion cell layer in PD group were negatively correlated with the MDS-UPDRS Il score and H-Y grade.

Conclusion: The ganglion cell layer in the macular region of patients with PD was thinnerand smaller, and the thickness and volume change more obviously with the aggravation of the disease. The thickness and volume of the ganglion cell layer in the macular area measured by OCT may be used as a biomarker of PD to provide some help for the early diagnosis and evaluation of the disease.