Parkinson's diseasePD)is the second most common neurodegenerative disorder after Alzheimer's disease and it is defned as a complex progressive neurodegenerative disorder referred by tremor, rigidity, bradykinesia, and postural imbalance because of progressive neuronal loss in the substantia nigra. PD usually accompanies with a numbel of non-motor symptoms, such as constipation, sleep disorder, depression, and also some other comorbidities, such as diabetes, coronary heart disease, osteoporosis. Circulatory system diseases are the most common comorbidities of PD. Circulatory system comorbidities of PD incude cardiac autonomic dysfunction, cardiomyopathy, coronary heart disease arrhythmias, sudden cardiac death (SCD), and sudden unexpected death in PD (SUDPAR).The most prominent circulatory system comorbidity is cardiac autonomic dysfunction. This review will analyze and discuss the circulatory system comorbidities of PD.