Objective: A case of glioblastoma associated with autoimmune encephalitis is reported to improve the understanding and diagnosis of this disease.

Methods: The diagnosis and treatment of a case of glioblastoma associated with autoimmune encephalitis were described in detail, and the clinical manifestations and treatment ideas of the disease were discussed.

Results: A patient presented dizziness, fatigue of both lower limbs, unstable gait.vagueness speech, and occasional dysphagia as the main clinical manifestations. Relevant examinations had been taken in hospital. Multiple abnormal signal images were observedon MRl. The serum N-methyl-D-Aspartate receptor (NMDAR) antibody lgG titer was 1:32.The serum anti-glial fbrillary acidic protein (GFAP) antibody titer was 1:10, and the cerebrospinal fluid anti-NMDAR antibody titer was 1:1. The pathological biopsy of intracranial lesion indicated “lDH1 wild type, glioblastoma, central nervous system (CNSWHO grade 4". This patient was diagnosed with glioblastoma associated with autoimmune encephalitis finally.

Conclusion: Glioblastoma could coexist with autoimmune encephalitis. These two diseases have similar clinical and imaging manifestations and it is prone to missed diagnosis and misdiagnosis in clinical practice. Therefore, attention should be paid to the diversity and comprehensiveness of disease diagnosis, At the same time, the immune reactivity of thebody can be used as a potential biomarker for early recognition of glioblastoma, and to provide effective intervention and improve the prognosis as soon as possible.